Article
A novel adipose-specific gene deletion model demonstrates potential pitfalls of existing methods.
Molecular endocrinology (Baltimore, Md.) - 1 Jan 2013
Mullican Shannon E, Tomaru Takuya, Gaddis Christine A, Peed Lindsey C, Sundaram Anand, Lazar Mitchell A
Abstract excerpt
Adipose-specific gene deletion in mice is crucial in determining gene function in adipocyte homeostasis and the development of obesity. We noted 100% mortality when the Hdac3 gene was conditionally deleted using Fabp4-Cre mice, the most commonly used model of adipose-targeted Cre recombinase. However, this surprising result was not reproduced using other models of adipose targeting of Cre, including a novel...
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