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Article

BRAF V600E and KRAS G12S mutations in peripheral nerve sheath tumours.

Histopathology - 1 Feb 2013

Serrano César, Simonetti Sara, Hernández-Losa Javier, Valverde Claudia, Carrato Cristina, Bagué Silvia, Orellana Ruth, Somoza Rosa, Moliné Teresa, Carles Joan, Huguet Pere, Romagosa Cleofé, Ramón y Cajal Santiago

Abstract excerpt

AIMS: Benign (BPNST) and malignant (MPNST) peripheral nerve sheath tumours occur either sporadically or are related to neurofibromatosis (NF). The mechanisms involved are well known in NF-related tumours, but still remain unclear in sporadic cases. Somatic BRAF and KRAS mutations represent the most frequent genetic events in melanocytic neoplastic lesions. Because melanocytes and Schwann cells both derive from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23190154
DOI: 10.1111/his.12021

Genes

BRAF
KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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