Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours.

The Journal of pathology - 1 Apr 2009

Bottillo Irene, Ahlquist Terje, Brekke Helge, Danielsen Stine A, van den Berg Eva, Mertens Fredrik, Lothe Ragnhild A, Dallapiccola Bruno

Abstract excerpt

Malignant peripheral nerve sheath tumours (MPNSTs) are a malignancy occurring with increased frequency in patients with neurofibromatosis type 1 (NF1). In contrast to the well-known spectrum of germline NF1 mutations, the information on somatic mutations in MPNSTs is limited. In this study, we screened NF1, KRAS, and BRAF in 47 MPNSTs from patients with (n = 25) and without (n = 22) NF1. In addition, DNA from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, High Pressure Liquid
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Nerve Sheath Neoplasms

Share to Neurofibromatosis 1

Share to Proto-Oncogene Proteins B-raf

Share to Proto-Oncogene Proteins p21(ras)

Share to ras Proteins

Source

Identifiers

PMID: 19142971
DOI: 10.1002/path.2494

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline and somatic NF1 mutations in sporadic and NF1-associated malignant peripheral nerve sheath tumours.PMID 19142971Read ↗

Exploring the somatic NF1 mutational spectrum associated with NF1 cutaneous neurofibromas.Semantic proximity Read ↗

Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs).Semantic proximity Read ↗

Germline and somatic NF1 gene mutations in plexiform neurofibromas.Semantic proximity Read ↗

Recent Advances in the Diagnosis and Pathogenesis of Neurofibromatosis Type 1 (NF1)-associated Peripheral Nervous System Neoplasms.Semantic proximity Read ↗

Constitutional NF1 mutations in neurofibromatosis 1 patients with malignant peripheral nerve sheath tumors.Semantic proximity Read ↗

The NF1 somatic mutational landscape in sporadic human cancers.Semantic proximity Read ↗

The heterogeneous nature of germline mutations in NF1 patients with malignant peripheral serve sheath tumours (MPNSTs)Semantic proximity Read ↗

Somatic alterations of the NF1 gene in an NF1 individual with multiple benign tumours (internal and external) and malignant tumour types.Semantic proximity Read ↗

Characterization of the somatic mutational spectrum of the neurofibromatosis type 1 (NF1) gene in neurofibromatosis patients with benign and malignant tumors.Semantic proximity Read ↗

Neurofibromatosis type 1-associated tumours: their somatic mutational spectrum and pathogenesis.Semantic proximity Read ↗

Frequent MN1 Gene Mutations in Malignant Peripheral Nerve Sheath Tumor.Semantic proximity Read ↗

Germline mutations in NF1 patients with malignanciesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.