Article
The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism.
PloS one - 1 Jan 2012
Zheng Xin, Vittar Natalia B Rumie, Gai Xiaohong, Fernandez-Barrena Maite G, Moser Catherine D, Hu Chunling, Almada Luciana L, McCleary-Wheeler Angela L, Elsawa Sherine F, Vrabel Anne M, Shire Abdirashid M, Comba Andrea, Thorgeirsson Snorri S, Kim Youngsoo, Liu Qingguang, Fernandez-Zapico Martin E, Roberts Lewis R
Abstract excerpt
The role of the epithelial-to-mesenchymal transition (EMT) during hepatocellular carcinoma (HCC) progression is well established, however the regulatory mechanisms modulating this phenomenon remain unclear. Here, we demonstrate that transcription factor glioma-associated oncogene 1 (GLI1) modulates EMT through direct up-regulation of SNAI1 and serves as a downstream effector of the transforming growth factor-β1...
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