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Article

Multidimensional analysis of gene expression reveals TGFB1I1-induced EMT contributes to malignant progression of astrocytomas.

Oncotarget - 30 Dec 2014

Liu Yanwei, Hu Huimin, Wang Kuanyu, Zhang Chuanbao, Wang Yinyan, Yao Kun, Yang Pei, Han Lei, Kang Chunsheng, Zhang Wei, Jiang Tao

Abstract excerpt

Malignant progression of astrocytoma is a multistep process with the integration of genetic abnormalities including grade progression and subtypes transition. Established biomarkers of astrocytomas, like IDH1 and TP53 mutation, were not associated with malignant progression. To identify new biomarker(s) contributing to malignant progression, we collected 252 samples with whole genome mRNA expression profile [34...

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Identifiers

PMID: 25333259
DOI: 10.18632/oncotarget.2518
PMCID: PMC4350345

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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