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Article

Association of germline variation in CCNE1 and CDK2 with breast cancer risk, progression and survival among Chinese Han women.

PloS one - 1 Jan 2012

Han Ji-Yuan, Wang Hui, Xie Yun-Tao, Li Yan, Zheng Li-Yuan, Ruan Yuan, Song Ai-Ping, Tian Xin-Xia, Fang Wei-Gang

Abstract excerpt

BACKGROUND: Somatic alterations of cyclin-dependent kinase 2 (CDK2)-cyclin E complex have been shown to contribute to breast cancer (BC) development and progression. This study aimed to explore the effects of single nucleotide polymorphisms (SNPs) in CDK2 and CCNE1 (a gene encoding G1/S specific cyclin E1 protein, formerly called cyclin E) on BC risk, progression and survival in a Chinese Han population....

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Identifiers

PMID: 23185313
DOI: 10.1371/journal.pone.0049296
PMCID: PMC3504019

Genes

CCNE1
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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