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Integrated analysis of cell cycle-related genes in HR+/HER2- breast cancer.

Breast cancer (Tokyo, Japan) - 1 Jan 2022

Lai Jianguo, Chen Bo, Li Yingzi, Lin Xiaoyi, Li Min, Liu Jing, Liao Ning

Abstract excerpt

PURPOSE: This study aimed to explore the mutational characteristics and significance of cell cycle-related genes (CCGs) in hormone-receptor positive, human epidermal growth factor receptor 2 negative breast cancer (HR+/HER2- BC). METHODS: A total of 1668 HR+/HER2- BC patients from the Guangdong Provincial People's Hospital (GDPH) cohort (n = 321) and METABRIC cohort (n = 1347) were included. Tumor samples from...

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PMID: 34449047
DOI: 10.1007/s12282-021-01289-y

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