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Article

The interplay between autophagy and ROS in tumorigenesis

1 Jan 2012

Abstract excerpt

Reactive oxygen species (ROS) at physiological levels are important cell signaling molecules. However, aberrantly high ROS are intimately associated with disease and commonly observed in cancer. Mitochondria are primary sources of intracellular ROS, and their maintenance is essential to cellular health. Autophagy, an evolutionarily conserved process whereby cytoplasmic components are delivered to lysosomes for...

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PMID: 23181220
DOI: 10.3389/fonc.2012.00171

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