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Tumor Suppression and Promotion by Autophagy

1 Jan 2014

Abstract excerpt

Autophagy is a highly regulated catabolic process that involves lysosomal degradation of proteins and organelles, mostly mitochondria, for the maintenance of cellular homeostasis and reduction of metabolic stress. Problems in the execution of this process are linked to different pathological conditions, such as neurodegeneration, aging, and cancer. Many of the proteins that regulate autophagy are either oncogenes...

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PMID: 25328887
DOI: 10.1155/2014/603980

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