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Article

ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy

13 Sept 2010

Abstract excerpt

Mounting evidence suggests that reactive oxygen species (ROS) are multifaceted signaling molecules implicated in a variety of cellular programs during physiological as well as pathological conditions. Recently, ROS produced endogenously, by deranged metabolism of cancer cells, or exogenously, by ROS-generating drugs, have been shown to promote macroautophagy, a lysosomal pathway of self-degradation with essential...

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PMID: 20505317
DOI: 10.4161/auto.6.7.12113

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