Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Retinal nerve fibre layer loss in hereditary spastic paraplegias is restricted to complex phenotypes.

BMC neurology - 23 Nov 2012

Wiethoff Sarah, Zhour Ahmad, Schöls Ludger, Fischer Manuel Dominik

Abstract excerpt

BACKGROUND: Reduction of retinal nerve fibre layer (RNFL) thickness was shown as part of the neurodegenerative process in a range of different neurodegenerative pathologies including Alzheimer's disease (AD), idiopathic Parkinson's disease (PD), spinocerebellar ataxia (SCA) and multiple system atrophy (MSA). To further clarify the specificity of RNFL thinning as a potential marker of neurodegenerative diseases we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Aged
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Fibers

Share to Retina

Share to Spastic Paraplegia, Hereditary

Share to Tomography, Optical Coherence

Share to Visual Acuity

Source

Open in PubMed Open full text

Identifiers

PMID: 23176075
DOI: 10.1186/1471-2377-12-143
PMCID: PMC3564819

Genes

SPG7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Retinal nerve fibre layer loss in hereditary spastic paraplegias is restricted to complex phenotypes.PMID 23176075Read ↗

Neurophysiological and ophthalmological findings of SPG7-related spastic ataxia: a phenotype study in an Irish cohort.Semantic proximity Read ↗

Retinal and pontine striations: neurodiagnostic signs of autosomal recessive spastic ataxia of Charlevoix-Saguenay.Semantic proximity Read ↗

Neuropsychology and MRI correlates of neurodegeneration in SPG11 hereditary spastic paraplegia.Semantic proximity Read ↗

Optical coherence tomography in autosomal recessive spastic ataxia of Charlevoix-Saguenay.Semantic proximity Read ↗

SPG11 mutations cause widespread white matter and basal ganglia abnormalities, but restricted cortical damage.Semantic proximity Read ↗

Loss of temporal retinal nerve fibers in Parkinson disease: a mitochondrial pattern?Semantic proximity Read ↗

Cortical thickness in ALS: towards a marker for upper motor neuron involvement.Semantic proximity Read ↗

Retinal axonal loss begins early in the course of multiple sclerosis and is similar between progressive phenotypes.Semantic proximity Read ↗

Thickness mapping of individual retinal layers and sectors by Spectralis SD-OCT in Autosomal Dominant Optic Atrophy.Semantic proximity Read ↗

Retinal photoreceptor layer thickness has disease specificity and distinguishes predicted FTLD-Tau from biomarker-determined Alzheimer's diseaseSemantic proximity Read ↗

Spastic Paraplegia Type 7-Associated Optic Neuropathy: A Case Series.Semantic proximity Read ↗

Clinical Features in Affected Individuals From 21 Pedigrees With Dominant Optic AtrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.