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Article

Insulin-Like Growth Factor II Targets the mTOR Pathway to Reverse Autism-Like Phenotypes in Mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Jan 2018

Steinmetz Adam B, Stern Sarah A, Kohtz Amy S, Descalzi Giannina, Alberini Cristina M

Abstract excerpt

Autism spectrum disorder (ASD) is a developmental disability characterized by impairments in social interaction and repetitive behavior, and is also associated with cognitive deficits. There is no current treatment that can ameliorate most of the ASD symptomatology; thus, identifying novel therapies is urgently needed. We used male BTBR T+Itpr3tf /J (BTBR) mice, a model that reproduces most of the core behavioral...

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Identifiers

PMID: 29217683
DOI: 10.1523/JNEUROSCI.2010-17.2017
PMCID: PMC5783959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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