Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deregulation of EIF4E: a novel mechanism for autism.

Journal of medical genetics - 1 Nov 2009

Neves-Pereira M, Müller B, Massie D, Williams J H G, O'Brien P C M, Hughes A, Shen S-B, Clair David St, Miedzybrodzka Z

Abstract excerpt

BACKGROUND: Autism is a common childhood onset neurodevelopmental disorder, characterised by severe and sustained impairment of social interaction and social communication, as well as a notably restricted repertoire of activities and interests. Its aetiology is multifactorial with a strong genetic basis. EIF4E is the rate limiting component of eukaryotic translation initiation, and plays a key role in learning...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autistic Disorder
Share to Brain
Share to Eukaryotic Initiation Factor-4E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to In Situ Hybridization, Fluorescence

Share to Mutagenesis, Insertional

Share to Sequence Alignment

Share to Translocation, Genetic

Source

Identifiers

PMID: 19556253
DOI: 10.1136/jmg.2009.066852

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deregulation of EIF4E: a novel mechanism for autism.PMID 19556253Read ↗

Autism-related deficits via dysregulated eIF4E-dependent translational control.Semantic proximity Read ↗

The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior.Semantic proximity Read ↗

Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorderSemantic proximity Read ↗

Genetic and Environmental Contributions to Autism Spectrum Disorder Through Mechanistic Target of RapamycinSemantic proximity Read ↗

Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorderSemantic proximity Read ↗

Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome.Semantic proximity Read ↗

Investigating the role of eukaryotic translation elongation factor eEF1A2 in autism, epilepsy and intellectual disabilitySemantic proximity Read ↗

Common EIF4E variants modulate risk for autism spectrum disorders in the high-functioning range.Semantic proximity Read ↗

FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to AutismSemantic proximity Read ↗

Neuronal Regulation of eIF2α Function in Health and Neurological Disorders.Semantic proximity Read ↗

Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes.Semantic proximity Read ↗

Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.