Article
[Relationship between Polymorphisms and the Efficacy of Cetuximab].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Oct 2015
Inoue Yuka, Hazama Shoichi, Tsunedomi Ryoichi, Takeda Shigeru, Ueno Tomio, Yamamoto Shigeru, Yoshino Shigefumi, Sakamoto Junichi, Mishima Hideyuki, Oka Masaaki, Nagano Hiroaki
Abstract excerpt
BACKGROUND AND OBJECTIVES: Cetuximab has shown efficacy in patients with metastatic colorectal cancer (mCRC). Recent studies have demonstrated that cetuximab induces antibody-dependent cell-mediated cytotoxicity (ADCC), mediated via the fragment c gamma receptors(FcgR)in mCRC. Since the establishment of KRAS mutations as a major negative predictor of efficacy, additional biomarkers have been found to be useful...
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