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Long-Term Exercise Modulates Hippocampal Gene Expression in Senescent Female Mice

21 Jan 2013

Abstract excerpt

The senescence-accelerated SAMP8 mouse is considered a useful non-transgenic model for studying aspects of progressive cognitive decline and Alzheimer's disease (AD). Using SAMR1 mice as controls, here we explored the effects of 6 months of voluntary wheel running in 10-month-old female SAMP8 mice. Exercise in SAMP8 mice improved phenotypic features associated with premature aging (i.e., skin color and body...

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PMID: 23168450
DOI: 10.3233/jad-121264

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