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Article

Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart.

Physiological genomics - 15 Jan 2003

Bronikowski A M, Carter P A, Morgan T J, Garland T, Ung N, Pugh T D, Weindruch R, Prolla T A

Abstract excerpt

We present the first quantitative gene expression analysis of cardiac aging under conditions of sedentary and active lifestyles using high-density oligonucleotide arrays representing 11,904 cDNAs and expressed sequence tags (ESTs). With these data, we test the hypothesis that exercise attenuates the gene expression changes that normally occur in the aging heart. Male mice (Mus domesticus) were sampled from the...

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Identifiers

PMID: 12429864
DOI: 10.1152/physiolgenomics.00082.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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