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Article

Establishment and characterization of two 5-fluorouracil-resistant hepatocellular carcinoma cell lines

15 Dec 2011

Abstract excerpt

5-Fluorouracil (5-FU) chemotherapy is the first choice treatment for advanced hepatocellular carcinoma (HCC), and resistance is the major obstacle to successful treatment. Recent studies have reported that epithelial-to-mesenchymal transition (EMT) is associated with chemoresistance in cancers. We speculated that EMT and 5-FU metabolism are related to the mechanism of 5-FU resistance. First, two 5-FU-resistant...

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Identifiers

PMID: 22179686
DOI: 10.3892/ijo.2011.1300

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