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Article

Proteomic investigation of 5‐fluorouracil resistance in a human hepatocellular carcinoma cell line

20 Dec 2011

Abstract excerpt

Multi-drug resistance (MDR) is a major obstacle towards a successful treatment of hepatocellular carcinoma (HCC). The mechanisms of MDR are intricate and have not been fully understood. Therefore, we employed a cell-line model consisting of the 5-fluorouracil (5-FU) resistant BEL7402/5-FU cell line and its parental BEL7402 cell line. Using relative and absolute quantification (iTRAQ)-coupled 2D LC-MS/MS, a...

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PMID: 22189913
DOI: 10.1002/jcb.24036

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