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Article

Ribosomes in the balance: structural equilibrium ensures translational fidelity and proper gene expression.

Nucleic acids research - 1 Dec 2014

Musalgaonkar Sharmishtha, Moomau Christine A, Dinman Jonathan D

Abstract excerpt

At equilibrium, empty ribosomes freely transit between the rotated and un-rotated states. In the cell, the binding of two translation elongation factors to the same general region of the ribosome stabilizes one state over the other. These stabilized states are resolved by expenditure of energy in the form of GTP hydrolysis. A prior study employing mutants of a late assembling peripheral ribosomal protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25389262
DOI: 10.1093/nar/gku1020
PMCID: PMC4245932

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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