Article
Zebrafish as a model for monocarboxyl transporter 8-deficiency.
The Journal of biological chemistry - 4 Jan 2013
Vatine Gad David, Zada David, Lerer-Goldshtein Tali, Tovin Adi, Malkinson Guy, Yaniv Karina, Appelbaum Lior
Abstract excerpt
Allan-Herndon-Dudley syndrome (AHDS) is a severe psychomotor retardation characterized by neurological impairment and abnormal thyroid hormone (TH) levels. Mutations in the TH transporter, monocarboxylate transporter 8 (MCT8), are associated with AHDS. MCT8 knock-out mice exhibit impaired TH levels; however, they lack neurological defects. Here, the zebrafish mct8 gene and promoter were isolated, and mct8...
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