Article
BRAF and GNAQ mutations in melanocytic tumors of the oral cavity.
Oral surgery, oral medicine, oral pathology and oral radiology - 1 Dec 2012
Cohen Yoram, Goldenberg-Cohen Nitza, Akrish Sharon, Shani Tali, Amariglio Ninette, Dratviman-Storobinsky Olga, Kaplan Ilana, Barshack Iris, Hirshberg Abraham
Abstract excerpt
OBJECTIVE: The genetic factors participating in oral melanoma evolution have not been studied extensively. We aimed to analyze the prevalence of BRAF and GNAQ mutations in a series of oral melanocytic tumors, nevi, and melanomas. STUDY DESIGN: The study group consisted of 4 melanomas and 10 nevi (6 intramucosal, 4 blue nevi). DNA was extracted from paraffin-embedded tissue sections, and mutations in GNAQ and BRAF...
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