Article
Unbalanced sample size effect on genome-wide population differentiation studies.
International journal of data mining and bioinformatics - 1 Jan 2012
Han Kyunghee, Kim Kyee-Zu, Oh Jung Mi, Kim In-Wha, Kim Kyungim, Park Taesung
Abstract excerpt
The fixation index (F(ST)) is one of the most widely used measurements of genetic distance between populations. The data set from the international HapMap project has been served as a reference data set for population differentiation studies. F(ST) is commonly used in order to compare the sample data with HapMap data. In this study, however, we show that the use of F(ST) without consideration of sample sizes may...
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