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Article

Transient acidification and subsequent proinflammatory cytokine stimulation of astrocytes induce distinct activation phenotypes.

Journal of cellular physiology - 1 Jun 2013

Renner Nicole A, Sansing Hope A, Inglis Fiona M, Mehra Smriti, Kaushal Deepak, Lackner Andrew A, Maclean Andrew G

Abstract excerpt

The foot processes of astrocytes cover over 60% of the surface of brain microvascular endothelial cells, regulating tight junction integrity. Retraction of astrocyte foot processes has been postulated to be a key mechanism in pathology. Therefore, movement of an astrocyte in response to a proinflammatory cytokine or even limited retraction of processes would result in leaky junctions between endothelial cells....

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Identifiers

PMID: 23154943
DOI: 10.1002/jcp.24283
PMCID: PMC3582839

Genes

GFAP
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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