Article

“Generation of morphologically distinct astrocyte subtypes from human iPSCs reveals a link between glial shape, function and reactivity”

2024-11-11

Abstract excerpt

Astrocyte morphology in vivo is heterogeneous across different subtypes and dynamically changes in response to various stimuli. However, several questions on the mechanistic links between shape and function remain unanswered. Here, we developed an efficient protocol to generate pure populations of morphologically distinct human astrocytes in vitro , which we used for a systematic analysis of shape-function relat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1b67f6fb-aef7-554a-aeeb-e5958a082708
DOI: 10.1101/2024.11.11.622998

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

“Generation of morphologically distinct astrocyte subtypes from human iPSCs reveals a link between glial shape, function and reactivity”DOI 10.1101/2024.11.11.622998Read

Diversity of astrocyte functions and phenotypes in neural circuits.Semantic proximity Read

Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective.Semantic proximity Read

Three-Dimensional Environment Sustains Morphological Heterogeneity and Promotes Phenotypic Progression During Astrocyte Development.Semantic proximity Read

An update on human astrocytes and their role in development and diseaseSemantic proximity Read

Human Astrocytes Exhibit Tumor Microenvironment-, Age-, and Sex-Related Transcriptomic SignaturesSemantic proximity Read

Diverse but unique astrocytic phenotypes during embryonic stem cell differentiation, culturing and agingSemantic proximity Read

Diverse But Unique Astrocytic Phenotypes During Embryonic Stem Cell Differentiation, Culturing and DevelopmentSemantic proximity Read

Molecular basis of astrocyte diversity and morphology across the CNS in health and diseaseSemantic proximity Read

Robust induction of functional astrocytes using NGN2 expression in human pluripotent stem cellsSemantic proximity Read

Generation of star-shaped human induced astrocytes with a mature inflammatory phenotype for CNS disease modelingSemantic proximity Read

Varicose-projection astrocytes: a reactive phenotype associated with neuropathologySemantic proximity Read

Phenotypic analysis of astrocytes derived from glial restricted precursors and their impact on axon regeneration.Semantic proximity Read