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Article

Functional analysis of the human tissue factor promoter and induction by serum.

Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 1990

Mackman N, Fowler B J, Edgington T S, Morrissey J H

Abstract excerpt

Tissue factor (TF) is the primary initiator of the coagulation protease cascades. This cell surface glycoprotein is the receptor and essential cofactor for the serine protease factor VIIa. TF is constitutively expressed in some extravascular cell types and is transiently induced in monocytes, endothelial cells, and fibroblasts. Inducible expression is implicated in cellular immune responses, inflammation, and...

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Identifiers

PMID: 2315317
DOI: 10.1073/pnas.87.6.2254
PMCID: PMC53665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Functional analysis of the human tissue factor promoter and induction by serum.PMID 2315317Read ↗

Regulation of the Tissue Factor GeneSemantic proximity Read ↗

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Transcriptional Regulation of the Tissue Factor Gene in Human Epithelial Cells Is Mediated by Sp1 and EGR-1Semantic proximity Read ↗

Regulation of the Tissue Factor Promoter in Endothelial CellsSemantic proximity Read ↗

The Transcriptional Program in the Response of Human Fibroblasts to SerumSemantic proximity Read ↗

Promoter elements in the transcriptional activation of the human stromelysin-1 gene by the inflammatory cytokine, interleukin 1.Semantic proximity Read ↗

Native and oxidized low density lipoprotein induction of tissue factor gene expression in smooth muscle cells is mediated by both Egr-1 and Sp1.Semantic proximity Read ↗

Functional dissection in vitro of the human c-fos promoter.Semantic proximity Read ↗

Functional Characterization of the Human Factor VII 5′-Flanking RegionSemantic proximity Read ↗

The Human ICAM-2 Promoter is Endothelial Cell-specific in Vitro and in Vivo and Contains Critical Sp1 and GATA Binding SitesSemantic proximity Read ↗

Polymorphisms in the 5'-UTR of the tissue factor gene are associated with altered expression in human endothelial cells.Semantic proximity Read ↗

Identification of a novel human tissue factor splice variant that is upregulated in tumor cellsSemantic proximity Read ↗

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