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Article

Gene and functional up-regulation of the BCRP/ABCG2 transporter in hepatocellular carcinoma

15 Nov 2012

Abstract excerpt

BACKGROUND: The Breast Cancer Resistance Protein (BCRP/ABCG2) is one member of ABC transporters proteins super family responsible of drug resistance. Since data on ABCG2 expression in liver malignances are scanty, here we report the expression of ABCG2 in adult human hepatocellular carcinoma (HCC) in both in vivo and in vitro models with different degree of malignancy. METHODS: In cell lines derived from human...

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PMID: 23153066
DOI: 10.1186/1471-230x-12-160

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