Article
IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Nov 2012
Emtage Lesley, Aziz-Zaman Sonya, Padovan-Merhar Olivia, Horvitz H Robert, Fang-Yen Christopher, Ringstad Niels
Abstract excerpt
To identify molecular mechanisms that function in G-protein signaling, we have performed molecular genetic studies of a simple behavior of the nematode Caenorhabditis elegans, egg laying, which is driven by a pair of serotonergic neurons, the hermaphrodite-specific neurons (HSNs). The activity of the HSNs is regulated by the G(o)-coupled receptor EGL-6, which mediates inhibition of the HSNs by neuropeptides. We...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Behavior, Animal
- Caenorhabditis elegans
- GTP-Binding Protein alpha Subunits, Gi-Go
- Genome
- Ion Channel Gating
- Molecular Sequence Data
- Neuropeptides
- Oocytes