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Article

IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Nov 2012

Emtage Lesley, Aziz-Zaman Sonya, Padovan-Merhar Olivia, Horvitz H Robert, Fang-Yen Christopher, Ringstad Niels

Abstract excerpt

To identify molecular mechanisms that function in G-protein signaling, we have performed molecular genetic studies of a simple behavior of the nematode Caenorhabditis elegans, egg laying, which is driven by a pair of serotonergic neurons, the hermaphrodite-specific neurons (HSNs). The activity of the HSNs is regulated by the G(o)-coupled receptor EGL-6, which mediates inhibition of the HSNs by neuropeptides. We...

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Identifiers

PMID: 23152612
DOI: 10.1523/JNEUROSCI.2667-12.2012
PMCID: PMC3544400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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