Article
An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression.
Human molecular genetics - 1 Sept 2016
Wyszynski Asaf, Hong Chi-Chen, Lam Kristin, Michailidou Kyriaki, Lytle Christian, Yao Song, Zhang Yali, Bolla Manjeet K, Wang Qin, Dennis Joe, Hopper John L, Southey Melissa C, Schmidt Marjanka K, Broeks Annegien, Muir Kenneth, Lophatananon Artitaya, Fasching Peter A, Beckmann Matthias W, Peto Julian, Dos-Santos-Silva Isabel, Sawyer Elinor J, Tomlinson Ian, Burwinkel Barbara, Marme Frederik, Guénel Pascal, Truong Thérèse, Bojesen Stig E, Nordestgaard Børge G, González-Neira Anna, Benitez Javier, Neuhausen Susan L, Brenner Hermann, Dieffenbach Aida Karina, Meindl Alfons, Schmutzler Rita K, Brauch Hiltrud, Nevanlinna Heli, Khan Sofia, Matsuo Keitaro, Ito Hidemi, Dörk Thilo, Bogdanova Natalia V, Lindblom Annika, Margolin Sara, Mannermaa Arto, Kosma Veli-Matti, Wu Anna H, Van Den Berg David, Lambrechts Diether, Wildiers Hans, Chang-Claude Jenny, Rudolph Anja, Radice Paolo, Peterlongo Paolo, Couch Fergus J, Olson Janet E, Giles Graham G, Milne Roger L, Haiman Christopher A, Henderson Brian E, Dumont Martine, Teo Soo Hwang, Wong Tien Y, Kristensen Vessela, Zheng Wei, Long Jirong, Winqvist Robert, Pylkäs Katri, Andrulis Irene L, Knight Julia A, Devilee Peter, Seynaeve Caroline, García-Closas Montserrat, Figueroa Jonine, Klevebring Daniel, Czene Kamila, Hooning Maartje J, van den Ouweland Ans M W, Darabi Hatef, Shu Xiao-Ou, Gao Yu-Tang, Cox Angela, Blot William, Signorello Lisa B, Shah Mitul, Kang Daehee, Choi Ji-Yeob, Hartman Mikael, Miao Hui, Hamann Ute, Jakubowska Anna, Lubinski Jan, Sangrajrang Suleeporn, McKay James, Toland Amanda E, Yannoukakos Drakoulis, Shen Chen-Yang, Wu Pei-Ei, Swerdlow Anthony, Orr Nick, Simard Jacques, Pharoah Paul D P, Dunning Alison M, Chenevix-Trench Georgia, Hall Per, Bandera Elisa, Amos Chris, Ambrosone Christine, Easton Douglas F, Cole Michael D
Abstract excerpt
Breast cancer is the most diagnosed malignancy and the second leading cause of cancer mortality in females. Previous association studies have identified variants on 2q35 associated with the risk of breast cancer. To identify functional susceptibility loci for breast cancer, we interrogated the 2q35 gene desert for chromatin architecture and functional variation correlated with gene expression. We report a novel...
