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Article

Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells.

Molecular pharmacology - 1 Feb 2013

Wu Alex Man Lai, Dalvi Pooja, Lu Xiaoli, Yang Mingdong, Riddick David S, Matthews Jason, Clevenger Charles V, Ross Douglas D, Harper Patricia A, Ito Shinya

Abstract excerpt

The multidrug transporter, breast cancer resistance protein, ABCG2, is up-regulated in certain chemoresistant cancer cells and in the mammary gland during lactation. We investigated the role of the lactogenic hormone prolactin (PRL) in the regulation of ABCG2. PRL dose-dependently induced ABCG2 e...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
Share to Carcinoma, Ductal, Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple

Share to Janus Kinase 2

Share to MCF-7 Cells

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Prolactin

Share to STAT5 Transcription Factor

Source

Identifiers

PMID: 23150485
DOI: 10.1124/mol.112.082362

Genes

ABCG2
PRL
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23150485-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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