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Article

Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization.

Nucleic acids research - 25 Feb 1990

Ruvkun G, Gilbert W, Horvitz H R

Abstract excerpt

We report a general method for the detection of restriction fragment length alterations associated with mutations or polymorphisms using whole genomic DNA rather than specific cloned DNA probes. We utilized a modified Southern Cross hybridization to display the hybridization pattern of all size-separated restriction fragments from wild-type Caenorhabditis elegans to all the corresponding fragments in a particular...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 2315039
DOI: 10.1093/nar/18.4.809
PMCID: PMC330331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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