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Article

Pre-capture multiplexing improves efficiency and cost-effectiveness of targeted genomic enrichment.

BMC genomics - 14 Nov 2012

Shearer A Eliot, Hildebrand Michael S, Ravi Harini, Joshi Swati, Guiffre Angelica C, Novak Barbara, Happe Scott, LeProust Emily M, Smith Richard J H

Abstract excerpt

BACKGROUND: Targeted genomic enrichment (TGE) is a widely used method for isolating and enriching specific genomic regions prior to massively parallel sequencing. To make effective use of sequencer output, barcoding and sample pooling (multiplexing) after TGE and prior to sequencing (post-capture multiplexing) has become routine. While previous reports have indicated that multiplexing prior to capture...

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PMID: 23148716
DOI: 10.1186/1471-2164-13-618
PMCID: PMC3534602

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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