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Article

Glutathione-S-transferase (GST) polymorphisms are associated with relapse after radical prostatectomy.

Prostate cancer and prostatic diseases - 1 Mar 2013

Cotignola J, Leonardi D B, Shahabi A, Acuña A D, Stern M C, Navone N, Scorticati C, De Siervi A, Mazza O, Vazquez E

Abstract excerpt

BACKGROUND: Organ confined prostate cancer (PCa) can be cured by radical retropubic prostatectomy (RRP); however, some tumors will still recur. Current tools fail to identify patients at risk of recurrence. Glutathione-S-transferases (GSTs) are involved in the metabolism of carcinogens, hormones and drugs. Thus, genetic polymorphisms that modify the GST activities may modify the risk of PCa recurrence. METHODS:...

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Source

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Identifiers

PMID: 23146971
DOI: 10.1038/pcan.2012.45
PMCID: PMC3626169

Genes

GSTM1
GSTP1
GSTT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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