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Article

Protein tyrosine phosphatase receptor type z negatively regulates oligodendrocyte differentiation and myelination.

PloS one - 1 Jan 2012

Kuboyama Kazuya, Fujikawa Akihiro, Masumura Makoto, Suzuki Ryoko, Matsumoto Masahito, Noda Masaharu

Abstract excerpt

BACKGROUND: Fyn tyrosine kinase-mediated down-regulation of Rho activity through activation of p190RhoGAP is crucial for oligodendrocyte differentiation and myelination. Therefore, the loss of function of its counterpart protein tyrosine phosphatase (PTP) may enhance myelination during development and remyelination in demyelinating diseases. To test this hypothesis, we investigated whether Ptprz, a receptor-like...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23144976
DOI: 10.1371/journal.pone.0048797
PMCID: PMC3492236

Genes

MBP
MOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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