Article
Effects of growth and mutation on pattern formation in tissues.
PloS one - 1 Jan 2012
Mengel Pers Benedicte, Krishna Sandeep, Chakraborty Sagar, Pigolotti Simone, Sekara Vedran, Semsey Szabolcs, Jensen Mogens H
Abstract excerpt
In many developing tissues, neighboring cells enter different developmental pathways, resulting in a fine-grained pattern of different cell states. The most common mechanism that generates such patterns is lateral inhibition, for example through Delta-Notch coupling. In this work, we simulate growth of tissues consisting of a hexagonal arrangement of cells laterally inhibiting their neighbors. We find that tissue...
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