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Article

In vivo capsular switch in Streptococcus pneumoniae--analysis by whole genome sequencing.

PloS one - 1 Jan 2012

Hu Fen Z, Eutsey Rory, Ahmed Azad, Frazao Nelson, Powell Evan, Hiller N Luisa, Hillman Todd, Buchinsky Farrel J, Boissy Robert, Janto Benjamin, Kress-Bennett Jennifer, Longwell Mark, Ezzo Suzanne, Post J Christopher, Nesin Mirjana, Tomasz Alexander, Ehrlich Garth D

Abstract excerpt

Two multidrug resistant strains of Streptococcus pneumoniae - SV35-T23 (capsular type 23F) and SV36-T3 (capsular type 3) were recovered from the nasopharynx of two adult patients during an outbreak of pneumococcal disease in a New York hospital in 1996. Both strains belonged to the pandemic lineage PMEN1 but they differed strikingly in virulence when tested in the mouse model of IP infection: as few as 1000 CFU...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23144841
DOI: 10.1371/journal.pone.0047983
PMCID: PMC3493582

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