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Article

Streptococcus pneumoniae clonal complex 199: genetic diversity and tissue-specific virulence.

PloS one - 14 Apr 2011

Thomas Jonathan C, Figueira Marisol, Fennie Kristopher P, Laufer Alison S, Kong Yong, Pichichero Michael E, Pelton Stephen I, Pettigrew Melinda M

Abstract excerpt

Streptococcus pneumoniae is an important cause of otitis media and invasive disease. Since introduction of the heptavalent pneumococcal conjugate vaccine, there has been an increase in replacement disease due to serotype 19A clonal complex (CC)199 isolates. The goals of this study were to 1) describe genetic diversity among nineteen CC199 isolates from carriage, middle ear, blood, and cerebrospinal fluid, 2)...

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Identifiers

PMID: 21533186
DOI: 10.1371/journal.pone.0018649
PMCID: PMC3077395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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