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Article

FRα expression in advanced endometrial carcinoma: Clinicopathological, molecular, and prognosis correlates.

Gynecologic oncology - 1 Jun 2025

Xiao Yinbo, Pang Junyi, Zhou Yang, Lu Junliang, Chen Longyun, Liu Hangqi, Shi Jing, Shi Xiaohua, Liang Zhiyong

Abstract excerpt

BACKGROUND: Advanced endometrial carcinoma (EC) is a therapeutic challenge with limited treatment options. Folate receptor alpha (FRα)-targeted antibody-drug conjugates (ADCs) are being explored for EC treatment. However, the molecular profiles of FRα-expressing ECs remain understudied. This study aims to evaluate FRα expression in advanced EC and its associations with clinicopathological features, molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40344965
DOI: 10.1016/j.ygyno.2025.05.001

Genes

PTEN
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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