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Bromodomain Protein Brd4 Plays a Key Role in Merkel Cell Polyomavirus DNA Replication

8 Nov 2012

Abstract excerpt

Merkel cell polyomavirus (MCV or MCPyV) is the first human polyomavirus to be definitively linked to cancer. The mechanisms of MCV-induced oncogenesis and much of MCV biology are largely unexplored. In this study, we demonstrate that bromodomain protein 4 (Brd4) interacts with MCV large T antigen (LT) and plays a critical role in viral DNA replication. Brd4 knockdown inhibits MCV replication, which can be rescued...

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PMID: 23144621
DOI: 10.1371/journal.ppat.1003021

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