Higher frequency of septic shock in septic patients with the 47C allele (rs4880) of the SOD2 gene.

doi:10.1016/j.gene.2012.10.078

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Article

Higher frequency of septic shock in septic patients with the 47C allele (rs4880) of the SOD2 gene.

Gene - 15 Mar 2013

Paludo Francis Jackson de Oliveira, Picanço Juliane Bentes, Fallavena Paulo Roberto Vargas, Fraga Lucas da Rosa, Graebin Pietra, Nóbrega Otávio de Toledo, Dias Fernando Suparregui, Alho Clarice Sampaio

Abstract excerpt

AIM: To analyze the effect of the two different versions of the manganese superoxide dismutase gene (SOD2) on sepsis. The SOD2 gene presents the 47C>T single nucleotide polymorphism (SNP; ID: rs4880) which produces MnSOD with different activities. The -9Val MnSOD (47T allele) is less efficient than the -9Ala version (47C allele). During sepsis there are abundance of ROS, high SOD2 expression and excess of...

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PMID: 23142385
DOI: 10.1016/j.gene.2012.10.078

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SOD2

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