Article
Aberrations in the epidermal growth factor receptor gene in 958 patients with diverse advanced tumors: implications for therapy.
Annals of oncology : official journal of the European Society for Medical Oncology - 1 Mar 2013
Wheler J J, Falchook G S, Tsimberidou A M, Hong D S, Naing A, Piha-Paul S A, Chen S S, Fu S, Stephen B, Fok J Y, Janku F, Kurzrock R
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor (EGFR) mutations are associated with the response to EGFR inhibitors in patients with non-small-cell lung cancer (NSCLC). We sought to investigate EGFR aberrations in patients with diverse advanced cancers. PATIENTS AND METHODS: Patients referred to the phase I clinic were evaluated for the presence of EGFR mutations and response to therapy. RESULTS: EGFR aberrations...
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