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Article

eLCR: electrochemical detection of single DNA base changes via ligase chain reaction.

Chemical communications (Cambridge, England) - 21 Dec 2012

Wee Eugene J H, Shiddiky Muhammad J A, Brown Melissa A, Trau Matt

Abstract excerpt

Simple, inexpensive and wide-scaled analysis of single DNA base changes ('point mutations' which include SNP's, somatic mutations and epigenetic changes) is one of the holy grail's of point-of-care diagnostics. Herein, we present eLCR: a simple methodology that fuses Ligase Chain Reaction (LCR) with electrochemical detection based on DNA-mediated charge transport. LCR generates long and short "knife" motifs...

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PMID: 23133830
DOI: 10.1039/c2cc35841g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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