Spleen endothelial cells from patients with myelofibrosis harbor the JAK2V617F mutation.

doi:10.1182/blood-2012-01-404889

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Article

Spleen endothelial cells from patients with myelofibrosis harbor the JAK2V617F mutation.

Blood - 10 Jan 2013

Rosti Vittorio, Villani Laura, Riboni Roberta, Poletto Valentina, Bonetti Elisa, Tozzi Lorenzo, Bergamaschi Gaetano, Catarsi Paolo, Dallera Elena, Novara Francesca, Massa Margherita, Campanelli Rita, Fois Gabriela, Peruzzi Benedetta, Lucioni Marco, Guglielmelli Paola, Pancrazzi Alessandro, Fiandrino Giacomo, Zuffardi Orsetta, Magrini Umberto, Paulli Marco, Vannucchi Alessandro M, Barosi Giovanni

Abstract excerpt

Increased microvessel density contributes to abnormal BM and spleen microenvironment in myelofibrosis (MF). Taking advantage of the JAK2V617F mutation as a marker of malignancy, in the present study, we investigated whether splenic endothelial cells (ECs) obtained from capillaries by laser microdissection or from fresh spleen tissue by cell culture or cell sorting harbored such mutation in patients bearing the...

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PMID: 23129323
DOI: 10.1182/blood-2012-01-404889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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