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The presence of JAK2V617F mutation in the liver endothelial cells of patients with Budd-Chiari syndrome

17 Mar 2009

Abstract excerpt

Patients with myeloproliferative disorders are at a high risk of developing thrombotic events. Several investigators have hypothesized that endothelial cell (EC) abnormalities might contribute to this prothrombotic state. Budd-Chiari syndrome (BCS) and portal vein thrombosis have been reported to be associated with JAK2V617F-positive hematopoiesis. We explored whether JAK2V617F was present in ECs in the vessels...

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PMID: 19293426
DOI: 10.1182/blood-2008-11-191544

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