Article
Frequent mutations in the RPL22 gene and its clinical and functional implications.
Gynecologic oncology - 1 Mar 2013
Novetsky Akiva P, Zighelboim Israel, Thompson Dominic M, Powell Matthew A, Mutch David G, Goodfellow Paul J
Abstract excerpt
OBJECTIVE: To determine the frequency and spectrum of mutations in RPL22 a gene identified by The Cancer Genome Atlas (TCGA) as mutated in endometrioid endometrial cancer, and determine the relationship between RPL22 defects and clinicopathologic features. METHODS: Direct sequencing of the entire coding region of the RPL22 cDNA and exons 2/4 was performed in tumors with/without microsatellite instability (MSI)....
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