Article

Genetic Variants in Recurrent Euploid Pregnancy Loss

2025-10-03

Abstract excerpt

Recurrent pregnancy loss (RPL) affects ∼5% of women, yet the genetic basis of euploid losses remains unclear. We performed genome sequencing in 118 families with unexplained euploid RPL, most without fetal anomalies. We identified genomic variants in 30 families (25.4%) across 28 genes. Thirteen genes were previously linked to perinatal lethality, while fifteen were novel. Inherited variants accounted for 83.3% (2...

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Literature Corpus work: 4e4eb195-f461-53de-9d4a-9f1482787cf0
DOI: 10.1101/2025.10.01.25335660

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