Article
Transplantation of GABAergic cells derived from bioreactor-expanded human neural precursor cells restores motor and cognitive behavioral deficits in a rodent model of Huntington's disease.
Cell transplantation - 1 Jan 2013
McLeod Marcus C, Kobayashi Nao R, Sen Arindom, Baghbaderani Behnam A, Sadi Damaso, Ulalia Ruperto, Behie Leo A, Mendez Ivar
Abstract excerpt
Huntington's disease (HD) is a neurodegenerative disorder that is characterized by progressive dementia, choreiform involuntary movements, and emotional deterioration. Neuropathological features include the progressive degeneration of striatal γ-aminobutyric acid (GABA) neurons. New therapeutic approaches, such as the transplantation of human neural precursor cells (hNPCs) to replace damaged or degenerated cells,...
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