Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease.

Cell transplantation - 1 Jan 2000

Armstrong R J, Watts C, Svendsen C N, Dunnett S B, Rosser A E

Abstract excerpt

Expanded neural precursor cells provide an attractive alternative to primary fetal tissue for cell replacement therapies in neurodegenerative diseases. In this study we transplanted epigenetically propagated human neural precursor cells into a rat model of Huntington's disease. Neural precursors survived transplantation and large numbers differentiated to express neuronal antigens, including some that expressed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholinesterase
Share to Brain Tissue Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopamine and cAMP-Regulated Phosphoprotein 32

Share to Fetal Tissue Transplantation

Share to Fibroblast Growth Factor 2

Share to Graft Survival

Share to Nerve Fibers

Share to Stem Cell Transplantation

Source

Identifiers

PMID: 10784067
DOI: 10.1177/096368970000900108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Survival, neuronal differentiation, and fiber outgrowth of propagated human neural precursor grafts in an animal model of Huntington's disease.PMID 10784067Read ↗

Histological findings on fetal striatal grafts in a Huntington's disease patient early after transplantation.Semantic proximity Read ↗

Migration patterns and phenotypic differentiation of long-term expanded human neural progenitor cells after transplantation into the adult rat brain.Semantic proximity Read ↗

Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology.Semantic proximity Read ↗

Integrating fetal neural transplants into a therapeutic strategy: the example of Huntington's disease.Semantic proximity Read ↗

The potential for circuit reconstruction by expanded neural precursor cells explored through porcine xenografts in a rat model of Parkinson's disease.Semantic proximity Read ↗

Reprogrammed Human Lateral Ganglionic Eminence Precursors Generate Striatal Neurons and Restore Motor Function in a Rat Model of Huntington’s DiseaseSemantic proximity Read ↗

Region-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat.Semantic proximity Read ↗

Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats.Semantic proximity Read ↗

Transplanted human neural precursor cells migrate widely but show no lesion-specific tropism in the 6-hydroxydopamine rat model of Parkinson's disease.Semantic proximity Read ↗

In vivo Ontogeny of human forebrain neural progenitor cell grafts in adult rats: an immunohistological studySemantic proximity Read ↗

Is there a place for human fetal-derived stem cells for cell replacement therapy in Huntington's disease?Semantic proximity Read ↗

Producing striatal phenotypes for transplantation in Huntington's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.