Article
Co-culture of healthy human keratinocytes and T-cells promotes keratinocyte chemokine production and RORγt-positive IL-17 producing T-cell populations.
Journal of dermatological science - 1 Jan 2013
Peters Jorieke H, Tjabringa Geuranne S, Fasse Esther, de Oliveira Vivian L, Schalkwijk Joost, Koenen Hans J P M, Joosten Irma
Abstract excerpt
BACKGROUND: Both keratinocytes and T-cells are crucial players in cutaneous immune responses. We hypothesized that direct interactions between keratinocytes and T-cell subsets could shape the nature or strength of the local immune response. OBJECTIVE: We investigated direct interactions between keratinocytes and T-cell subsets, focused on keratinocyte chemokine production and T-cell phenotype and cytokine...
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