Article
Sensitive measurement of single-nucleotide polymorphism-induced changes of RNA conformation: application to disease studies.
Nucleic acids research - 7 Jan 2013
Salari Raheleh, Kimchi-Sarfaty Chava, Gottesman Michael M, Przytycka Teresa M
Abstract excerpt
Single-nucleotide polymorphisms (SNPs) are often linked to critical phenotypes such as diseases or responses to vaccines, medications and environmental factors. However, the specific molecular mechanisms by which a causal SNP acts is usually not obvious. Changes in RNA secondary structure emerge as a possible explanation necessitating the development of methods to measure the impact of single-nucleotide variation...
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