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Article

ADAM‐10 is overexpressed in rheumatoid arthritis synovial tissue and mediates angiogenesis

2 Nov 2012

Abstract excerpt

OBJECTIVE: To examine the expression of ADAM-10 in rheumatoid arthritis (RA) synovial tissue (ST) and the role it plays in angiogenesis. METHODS: ADAM-10 expression was determined using immunohistology, Western blotting, and quantitative polymerase chain reaction. In order to examine the role of ADAM-10 in angiogenesis, we performed in vitro Matrigel tube formation and chemotaxis assays using human microvascular...

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PMID: 23124962
DOI: 10.1002/art.37755

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